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Effects of a Mediterranean-style diet on the need for antihyperglycemic drug therapy in patients with newly diagnosed type 2 diabetes: a randomised trial

In rats, the highest dose was approximately 131-times (males) and 186-times (females) the clinical dose of 10 mg per day, based on AUC exposure

Notably, pro-inflammatory cytokines are also secreted by visceral adipose tissue in obesity and, together with the inhibition of IRS-1 mediated by TNF-, inhibition of c-Jun N-terminal kinase (JNK) and NK- B inhibitor, serve as major inflammatory mechanisms linking obesity with IR [75, 82]

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